Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.

A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-...

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Bibliographic Details
Main Authors: Anagnou, N P, Ley, T J, Chesbro, B, Wright, G, Kitchens, C, Liebhaber, S, Nienhuis, A W, Deisseroth, A B
Format: Artigo
Language:Inglês
Published: 1983
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC534358/
https://ncbi.nlm.nih.gov/pubmed/6136971
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