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Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.

A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-...

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Main Authors: Anagnou, N P, Ley, T J, Chesbro, B, Wright, G, Kitchens, C, Liebhaber, S, Nienhuis, A W, Deisseroth, A B
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1983
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC534358/
https://ncbi.nlm.nih.gov/pubmed/6136971
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