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Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1983
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534358/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6136971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.19.6051 |
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