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Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.

The alpha-globin polypeptide is encoded by two adjacent genes, alpha 1 and alpha 2. In the normal diploid state (alpha alpha/alpha alpha) all four alpha-globin genes are expressed. Loss or dysfunction of one or more of these genes leads to deficient alpha-globin production and results in alpha-thala...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Liebhaber, S A, Kan, Y W
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1981
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6894931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110273
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