RORγt expression in T(regs) promotes systemic lupus erythematosus via IL‐17 secretion, alteration of T(reg) phenotype and suppression of Th2 responses

Systemic lupus erythematosus (SLE) is a common autoimmune disorder with a complex and poorly understood immunopathogenesis. However, a pathogenic role for the T helper type 17 (Th17) axis was demonstrated by many studies, while regulatory T cells (T(regs)) were shown to mediate protection. Recently,...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Kluger, M. A., Nosko, A., Ramcke, T., Goerke, B., Meyer, M. C., Wegscheid, C., Luig, M., Tiegs, G., Stahl, R. A. K., Steinmetz, O. M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343349/
https://ncbi.nlm.nih.gov/pubmed/27880975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12905
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