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Leptin-induced RORγt expression in CD4(+) T cells promotes Th17 responses in systemic lupus erythematosus()
Th17 CD4(+) cells promote inflammation and autoimmunity. Here we report that Th17 cell frequency is reduced in ob/ob mice that are genetically deficient in the adipokine leptin, and that the administration of leptin to ob/ob mice restored Th17 cell numbers to values comparable to those found in wild...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608794/ https://ncbi.nlm.nih.gov/pubmed/23447682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203275 |
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