The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity

Nuclear factor erythroid 2-related factor 2 (Nrf2) provides a cellular defense against oxidative stress by inducing the expression of antioxidant and detoxification enzymes. The calcium antagonist, verapamil, is an FDA-approved drug prescribed for the treatment of hypertension. Here, we show that ve...

Full description

Saved in:
Bibliographic Details
Published in:BMB Rep
Main Authors: Lee, Da Hyun, Park, Jeong Su, Lee, Yu Seol, Sung, Su Haeng, Lee, Yong-ho, Bae, Soo Han
Format: Artigo
Language:Inglês
Published: Korean Society for Biochemistry and Molecular Biology 2017
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342872/
https://ncbi.nlm.nih.gov/pubmed/27998394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2017.50.2.188
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items