TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

During apoptosis induction by TNF, the extrinsic and intrinsic apoptosis pathways converge at the lysosomal-mitochondrial interface. Earlier studies showed that the lysosomal aspartic protease Cathepsin D (CtsD) cleaves Bid to tBid, resulting in the amplification of the initial apoptotic cascade via...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fritsch, Jürgen, Fickers, Ricarda, Klawitter, Jan, Särchen, Vinzenz, Zingler, Philipp, Adam, Dieter, Janssen, Ottmar, Krause, Eberhard, Schütze, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342777/
https://ncbi.nlm.nih.gov/pubmed/27716614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12411
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