Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

ERCC1-XPF heterodimer is a 5′-3′ structure-specific endonuclease which is essential in multiple DNA repair pathways in mammalian cells. ERCC1-XPF (ERCC1-ERCC4) repairs cisplatin-DNA intrastrand adducts and interstrand crosslinks and its specific inhibition has been shown to enhance cisplatin cytotox...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Arora, Sanjeevani, Heyza, Joshua, Zhang, Hao, Kalman-Maltese, Vivian, Tillison, Kristin, Floyd, Ashley M., Chalfin, Elaine M., Bepler, Gerold, Patrick, Steve M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342726/
https://ncbi.nlm.nih.gov/pubmed/27650543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12072
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