Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells

The 5′-3′ structure-specific endonuclease ERCC1/XPF (Excision Repair Cross-Complementation Group 1/Xeroderma Pigmentosum group F) plays critical roles in the repair of cisplatin-induced DNA damage. As such, it has been identified as a potential pharmacological target for enhancing clinical response...

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Detalhes bibliográficos
Publicado no:Nutrients
Main Authors: Heyza, Joshua R., Arora, Sanjeevani, Zhang, Hao, Conner, Kayla L., Lei, Wen, Floyd, Ashley M., Deshmukh, Rahul R., Sarver, Jeffrey, Trabbic, Christopher J., Erhardt, Paul, Chan, Tak-Hang, Dou, Q. Ping, Patrick, Steve M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267282/
https://ncbi.nlm.nih.gov/pubmed/30400270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu10111644
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