Imaging extracellular lactate in vitro and in vivo using CEST MRI and a paramagnetic shift reagent

Overproduction of lactate is a hallmark of cancer yet a method to quantitatively measure lactate production by cancer cells is not straight-forward. CEST MRI can potentially be used to image lactate but the small difference in chemical shift of the lactate -OH proton and water proton resonances make...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Zhang, Lei, Martins, André, Mai, Yuyan, Zhao, Piyu, Funk, Alexander, Jordan, M. Veronica Clavijo, Zhang, Shanrong, Chen, Wei, Wu, Yunkou, Sherry, A. Dean
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342626/
https://ncbi.nlm.nih.gov/pubmed/27987233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201604558
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