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Oxidative conversion of a Eu(II)-based T(1) agent to a Eu(III)-based paraCEST agent can be detected in vivo by MRI
In this work, we demonstrate that Eu(II) complex of DOTA-tetra(glycinate) has a higher reduction potential than most Eu(II) chelates reported so far. The reduced Eu(II) form acts as an efficient water proton T(1) relaxation reagent while the Eu(III) form acts as a water-based CEST agent. The complex...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955383/ https://ncbi.nlm.nih.gov/pubmed/26954661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201511649 |
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