Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

A poor prognosis subtype of acute myeloid leukemia (AML) is characterized by increased expression of a set of homeodomain (HD) transcription factors, including HoxA9, HoxA10 and Cdx4. This encompasses AML with MLL1 gene translocations, because Mll1-fusion proteins aberrantly activate HOX transcripti...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Shah, Chirag A., Bei, Ling, Wang, Hao, Altman, Jessica K., Platanias, Leonidas C., Eklund, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342381/
https://ncbi.nlm.nih.gov/pubmed/27340869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10189
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