The Leukemia-associated Mll-Ell Oncoprotein Induces Fibroblast Growth Factor 2 (Fgf2)-dependent Cytokine Hypersensitivity in Myeloid Progenitor Cells

The subset of acute myeloid leukemias (AML) with chromosomal translocations involving the MLL gene have a poor prognosis (referred to as 11q23-AML). The MLL fusion proteins that are expressed in 11q23-AML facilitate transcription of a set of HOX genes, including HOXA9 and HOXA10. Because Hox protein...

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Detalhes bibliográficos
Main Authors: Shah, Chirag A., Bei, Ling, Wang, Hao, Platanias, Leonidas C., Eklund, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820883/
https://ncbi.nlm.nih.gov/pubmed/24089521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496109
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