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Constitutively Active SHP2 Cooperates with HoxA10 Overexpression to Induce Acute Myeloid Leukemia

The homeodomain transcription factor HoxA10 is maximally expressed in myeloid progenitor cells. Sustained HoxA10 expression during differentiation has been described in poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered overexpression of HoxA10 in murine bone marrow...

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Main Authors: Wang, Hao, Lindsey, Stephan, Konieczna, Iwona, Bei, Ling, Horvath, Elizabeth, Huang, Weiqi, Saberwal, Gurveen, Eklund, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629090/
https://ncbi.nlm.nih.gov/pubmed/19022774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804704200
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