Constitutively Active SHP2 Cooperates with HoxA10 Overexpression to Induce Acute Myeloid Leukemia

The homeodomain transcription factor HoxA10 is maximally expressed in myeloid progenitor cells. Sustained HoxA10 expression during differentiation has been described in poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered overexpression of HoxA10 in murine bone marrow...

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Bibliografiske detaljer
Main Authors: Wang, Hao, Lindsey, Stephan, Konieczna, Iwona, Bei, Ling, Horvath, Elizabeth, Huang, Weiqi, Saberwal, Gurveen, Eklund, Elizabeth A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629090/
https://ncbi.nlm.nih.gov/pubmed/19022774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804704200
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