Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis

Cdx and Hox proteins are homeodomain transcription factors that regulate hematopoiesis. Transcription of the HOX and CDX genes decreases during normal myelopoiesis, but is aberrantly sustained in leukemias with translocation or partial tandem duplication of the MLL1 gene. Cdx4 activates transcriptio...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Bei, L, Shah, C, Wang, H, Huang, W, Platanias, L C, Eklund, E A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275563/
https://ncbi.nlm.nih.gov/pubmed/25531430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.49
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