Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19(+)- liver cells deficient for p53 and Rb

The long term prognosis of liver cancer patients remains unsatisfactory because of cancer recurrence after surgical interventions, particularly in patients with viral infections. Since hepatitis B and C viral proteins lead to inactivation of the tumor suppressors p53 and Retinoblastoma (Rb), we hypo...

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Udgivet i:Oncotarget
Main Authors: Matondo, Ramadhan B, Toussaint, Mathilda JM, Govaert, Klaas M, van Vuuren, Luciel D, Nantasanti, Sathidpak, Nijkamp, Maarten W, Pandit, Shusil K, Tooten, Peter CJ, Koster, Mirjam H, Holleman, Kaylee, Schot, Arend, Gu, Guoqiang, Spee, Bart, Roskams, Tania, Rinkes, Inne Borel, Schotanus, Baukje, Kranenburg, Onno, de Bruin, Alain
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342371/
https://ncbi.nlm.nih.gov/pubmed/27323406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9952
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