Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1

Broadly-neutralizing monoclonal antibodies (bNAbs) may guide vaccine development for highly variable viruses including hepatitis C virus (HCV), since they target conserved viral epitopes that could serve as vaccine antigens. However, HCV resistance to bNAbs could reduce the efficacy of a vaccine. HC...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: El-Diwany, Ramy, Cohen, Valerie J., Mankowski, Madeleine C., Wasilewski, Lisa N., Brady, Jillian K., Snider, Anna E., Osburn, William O., Murrell, Ben, Ray, Stuart C., Bailey, Justin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342271/
https://ncbi.nlm.nih.gov/pubmed/28235087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006235
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