Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L

Neuroblastoma is the most common extracranial solid tumor during infancy and childhood. Outcome of high-risk and late-stage disease remains poor despite intensive treatment regimens. Suppressing inhibitor of apoptosis proteins (IAPs) using Smac mimetics (SM) significantly sensitizes neuroblastoma (N...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Najem, Safiullah, Langemann, Doerte, Appl, Birgit, Trochimiuk, Magdalena, Hundsdoerfer, Patrick, Reinshagen, Konrad, Eschenburg, Georg
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341933/
https://ncbi.nlm.nih.gov/pubmed/27655666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12055
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