Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α

We demonstrated sensitization for chemotherapy by Smac mimetic (SM) LCL161, a potent antagonist of inhibitor of apoptosis proteins (IAP), in neuroblastoma (NB). Vinca alkaloids, particularly vincristine (VCR), displayed the strongest impact on inhibition of proliferation and apoptosis induction in c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Langemann, Doerte, Trochimiuk, Magdalena, Appl, Birgit, Hundsdoerfer, Patrick, Reinshagen, Konrad, Eschenburg, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675670/
https://ncbi.nlm.nih.gov/pubmed/29152118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21193
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