PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity

Acute promyelocitic leukemia (APL) is characterized by the pathognomonic presence in leukemic blasts of the hybrid protein PML/RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid differentiation. Here, we show that primary blasts from APL pat...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Noguera, Nélida Inés, Piredda, Maria Liliana, Taulli, Riccardo, Catalano, Gianfranco, Angelini, Giulia, Gaur, Girish, Nervi, Clara, Voso, Maria Teresa, Lunardi, Andrea, Pandolfi, Pier Paolo, Lo-Coco, Francesco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341808/
https://ncbi.nlm.nih.gov/pubmed/27626703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11964
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