Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-Ras(G12V)–induced squamous tumors

Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. In two doxycycline-inducible models where oncogenic H-Ras(G12V) is targeted either to the epidermal basal/stem cell layer with a Keratin14-rtTA transgene (K14Ras), or committed progeni...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Podolsky, Michael A., Bailey, Jacob T., Gunderson, Andrew J., Oakes, Carrie J., Breech, Kyle, Glick, Adam B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341741/
https://ncbi.nlm.nih.gov/pubmed/28137717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0304
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