CD8(+) T cells Mediate RAS-induced Psoriasis-like Skin Inflammation Through IFN-γ

The RAS signaling pathway is constitutively activated in psoriatic keratinocytes. We expressed activated H-RAS(V12G) in suprabasal keratinocytes of adult mice and observed rapid development of a psoriasis-like skin phenotype characterized by basal keratinocyte hyperproliferation, acanthosis, hyperke...

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Detalhes bibliográficos
Main Authors: Gunderson, Andrew J., Mohammed, Javed, Horvath, Frank, Podolsky, Michael, Anderson, Cherie, Glick, Adam B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577939/
https://ncbi.nlm.nih.gov/pubmed/23151849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.390
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