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CD8(+) T cells Mediate RAS-induced Psoriasis-like Skin Inflammation Through IFN-γ
The RAS signaling pathway is constitutively activated in psoriatic keratinocytes. We expressed activated H-RAS(V12G) in suprabasal keratinocytes of adult mice and observed rapid development of a psoriasis-like skin phenotype characterized by basal keratinocyte hyperproliferation, acanthosis, hyperke...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3577939/ https://ncbi.nlm.nih.gov/pubmed/23151849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.390 |
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