ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Oncogenic Ras causes proliferation followed by premature senescence in primary cells, an initial barrier to tumor development. The role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in regulating these two cellular outcomes is poorly understood. During ER stress, the i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Blazanin, Nicholas, Son, Jeongin, Craig-Lucas, Alayna B., John, Christian L., Breech, Kyle J., Podolsky, Michael A., Glick, Adam B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603998/
https://ncbi.nlm.nih.gov/pubmed/28847931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701757114
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