TGFβ2 Induces the Formation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells Through the Smad and Non-Smad Dependent Pathways

PURPOSE: Increased intraocular pressure results from increased aqueous humor (AH) outflow resistance at the trabecular meshwork (TM) due to pathologic changes including the formation of cross-linked actin networks (CLANs). Transforming growth factor β2 (TGFβ2) is elevated in the AH and TM of primary...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Montecchi-Palmer, Michela, Bermudez, Jaclyn Y., Webber, Hannah C., Patel, Gaurang C., Clark, Abbot F., Mao, Weiming
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2017
Matèries:
Glaucoma
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341625/
https://ncbi.nlm.nih.gov/pubmed/28241317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19672
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