HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork

PURPOSE: Elevated intraocular pressure (IOP) in primary open-angle glaucoma (POAG) results from glaucomatous damage to the trabecular meshwork (TM). The glaucoma-associated factor TGFβ2 is increased in aqueous humor and TM of POAG patients. We hypothesize that histone acetylation has a role in dysre...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Bermudez, Jaclyn Y., Webber, Hannah C., Patel, Gaurang C., Liu, Xiangyang, Cheng, Yi-Qiang, Clark, Abbot F., Mao, Weiming
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2016
Fag:
Glaucoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973502/
https://ncbi.nlm.nih.gov/pubmed/27403998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs16-19446
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