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Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

BACKGROUND: Drugs often kill some cancer cells while others survive. This stochastic outcome is seen even in clonal cells grown under the same conditions. Understanding the molecular reasons for this stochastic outcome is a current challenge, which requires studying the proteome at the single cell l...

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Detalhes bibliográficos
Publicado no:BMC Syst Biol
Main Authors: Zimmer, Anat, Amar-Farkash, Shlomit, Danon, Tamar, Alon, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341406/
https://ncbi.nlm.nih.gov/pubmed/28270142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0410-8
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