Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells

To understand gene function, genetic analysis uses large perturbations such as gene deletion, knockdown or over-expression. Large perturbations have drawbacks: they move the cell far from its normal working point, and can thus be masked by off-target effects or compensation by other genes. Here, we...

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Detalhes bibliográficos
Main Authors: Farkash-Amar, Shlomit, Zimmer, Anat, Eden, Eran, Cohen, Ariel, Geva-Zatorsky, Naama, Cohen, Lydia, Milo, Ron, Sigal, Alex, Danon, Tamar, Alon, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945223/
https://ncbi.nlm.nih.gov/pubmed/24603725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004176
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