Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells

To understand gene function, genetic analysis uses large perturbations such as gene deletion, knockdown or over-expression. Large perturbations have drawbacks: they move the cell far from its normal working point, and can thus be masked by off-target effects or compensation by other genes. Here, we...

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Autori principali: Farkash-Amar, Shlomit, Zimmer, Anat, Eden, Eran, Cohen, Ariel, Geva-Zatorsky, Naama, Cohen, Lydia, Milo, Ron, Sigal, Alex, Danon, Tamar, Alon, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945223/
https://ncbi.nlm.nih.gov/pubmed/24603725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004176
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