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Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

BACKGROUND: Drugs often kill some cancer cells while others survive. This stochastic outcome is seen even in clonal cells grown under the same conditions. Understanding the molecular reasons for this stochastic outcome is a current challenge, which requires studying the proteome at the single cell l...

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Podrobná bibliografie
Vydáno v:BMC Syst Biol
Hlavní autoři: Zimmer, Anat, Amar-Farkash, Shlomit, Danon, Tamar, Alon, Uri
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341406/
https://ncbi.nlm.nih.gov/pubmed/28270142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0410-8
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