An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele

Natural killer (NK) cells are known to play a role in mediating innate immunity, in enhancing adaptive immune responses, and have been implicated in mediating anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC) by reactivity of CD16 with the Fc region of human IgG1 antibodi...

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Pubblicato in:Oncotarget
Autori principali: Jochems, Caroline, Hodge, James W., Fantini, Massimo, Fujii, Rika, Maurice, Y. Morillon, Greiner, John W., Padget, Michelle R., Tritsch, Sarah R., Tsang, Kwong Yok, Campbell, Kerry S., Klingemann, Hans, Boissel, Laurent, Rabizadeh, Shahrooz, Soon-Shiong, Patrick, Schlom, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341330/
https://ncbi.nlm.nih.gov/pubmed/27861156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13411
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