The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

BACKGROUND: Gab1 is a docking protein that recruits phosphatidylinositol-3 kinase (PI-3 kinase) and other effector proteins in response to the activation of many receptor tyrosine kinases (RTKs). As the autophosphorylation sites on EGF-receptor (EGFR) do not include canonical PI-3 kinase binding sit...

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Main Authors: Mattoon, Dawn R, Lamothe, Betty, Lax, Irit, Schlessinger, Joseph
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2004
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC534114/
https://ncbi.nlm.nih.gov/pubmed/15550174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-2-24
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