Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease

Male sex predisposes to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within the kidney, we hypothesized that dihydrotestosterone (DHT) would alter the biology of the renal tubular cell by inducing changes in the proteome. We employed stable is...

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Detalles Bibliográficos
Publicado en:Mol Cell Proteomics
Main Authors: Clotet, Sergi, Soler, Maria Jose, Riera, Marta, Pascual, Julio, Fang, Fei, Zhou, Joyce, Batruch, Ihor, Vasiliou, Stella K., Dimitromanolakis, Apostolos, Barrios, Clara, Diamandis, Eleftherios P., Scholey, James W., Konvalinka, Ana
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341000/
https://ncbi.nlm.nih.gov/pubmed/28062795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.061903
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