Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro

Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are captured by the urinary peptidome. To elucidate the early kidney response to chronic hyperglycemia, we conducted a pep...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Van, Julie A. D., Clotet-Freixas, Sergi, Zhou, Joyce, Batruch, Ihor, Sun, Chunxiang, Glogauer, Michael, Rampoldi, Luca, Elia, Yesmino, Mahmud, Farid H., Sochett, Etienne, Diamandis, Eleftherios P., Scholey, James W., Konvalinka, Ana
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050109/
https://ncbi.nlm.nih.gov/pubmed/31879271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001858
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