Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor

Extending the scope of biocatalysis to important non-natural reactions such as olefin cyclopropanation will open new opportunities for replacing multi-step chemical syntheses of pharmaceutical intermediates with efficient, clean, and highly selective enzyme-catalyzed processes. In this work, we engi...

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Bibliographic Details
Published in:ACS Catal
Main Authors: Hernandez, Kari E., Renata, Hans, Lewis, Russell D., Jennifer Kan, S. B., Zhang, Chen, Forte, Jared, Rozzell, David, McIntosh, John A., Arnold, Frances H.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340201/
https://ncbi.nlm.nih.gov/pubmed/28286694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.6b02550
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