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Biocatalytic strategy for the highly stereoselective synthesis of CHF(2)-containing trisubstituted cyclopropanes
The difluoromethyl (CHF(2)) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocatalytic method for the highly diastereo- and enantiosel...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7969403/ https://ncbi.nlm.nih.gov/pubmed/33337576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015895 |
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