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Biocatalytic strategy for the highly stereoselective synthesis of CHF(2)-containing trisubstituted cyclopropanes
The difluoromethyl (CHF(2)) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocatalytic method for the highly diastereo- and enantiosel...
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| Publié dans: | Angew Chem Int Ed Engl |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7969403/ https://ncbi.nlm.nih.gov/pubmed/33337576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015895 |
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