Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity

DNA polymerase catalyzes the accurate transfer of genetic information from one generation to the next, and thus it is vitally important for replication to be faithful. DNA polymerase fulfills the strict requirements for fidelity by a combination of mechanisms: 1) high selectivity for correct nucleot...

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Publicat a:Biophys J
Autors principals: Hoekstra, Tjalle P., Depken, Martin, Lin, Szu-Ning, Cabanas-Danés, Jordi, Gross, Peter, Dame, Remus T., Peterman, Erwin J.G., Wuite, Gijs J.L.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2017
Matèries:
Nucleic Acids and Genome Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340169/
https://ncbi.nlm.nih.gov/pubmed/28256218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.044
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