Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity

DNA polymerase catalyzes the accurate transfer of genetic information from one generation to the next, and thus it is vitally important for replication to be faithful. DNA polymerase fulfills the strict requirements for fidelity by a combination of mechanisms: 1) high selectivity for correct nucleot...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Hoekstra, Tjalle P., Depken, Martin, Lin, Szu-Ning, Cabanas-Danés, Jordi, Gross, Peter, Dame, Remus T., Peterman, Erwin J.G., Wuite, Gijs J.L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Nucleic Acids and Genome Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340169/
https://ncbi.nlm.nih.gov/pubmed/28256218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.044
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