Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity

DNA polymerase catalyzes the accurate transfer of genetic information from one generation to the next, and thus it is vitally important for replication to be faithful. DNA polymerase fulfills the strict requirements for fidelity by a combination of mechanisms: 1) high selectivity for correct nucleot...

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Vydáno v:Biophys J
Hlavní autoři: Hoekstra, Tjalle P., Depken, Martin, Lin, Szu-Ning, Cabanas-Danés, Jordi, Gross, Peter, Dame, Remus T., Peterman, Erwin J.G., Wuite, Gijs J.L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Nucleic Acids and Genome Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340169/
https://ncbi.nlm.nih.gov/pubmed/28256218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.044
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