Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity

DNA polymerase catalyzes the accurate transfer of genetic information from one generation to the next, and thus it is vitally important for replication to be faithful. DNA polymerase fulfills the strict requirements for fidelity by a combination of mechanisms: 1) high selectivity for correct nucleot...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Hoekstra, Tjalle P., Depken, Martin, Lin, Szu-Ning, Cabanas-Danés, Jordi, Gross, Peter, Dame, Remus T., Peterman, Erwin J.G., Wuite, Gijs J.L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2017
Materias:
Nucleic Acids and Genome Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340169/
https://ncbi.nlm.nih.gov/pubmed/28256218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.044
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