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5-Fluorouracil Enhances Exosome-Dependent Accumulation of Polyadenylated rRNAs
The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of solid tumors. Although 5FU slows DNA synthesis by inhibiting the ability of thymidylate synthetase to produce dTMP, the drug also has significant effects on RNA metabolism. Recent genome-wide assays for 5F...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC533989/ https://ncbi.nlm.nih.gov/pubmed/15572680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10766-10776.2004 |
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