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5-Fluorouracil Enhances Exosome-Dependent Accumulation of Polyadenylated rRNAs
The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of solid tumors. Although 5FU slows DNA synthesis by inhibiting the ability of thymidylate synthetase to produce dTMP, the drug also has significant effects on RNA metabolism. Recent genome-wide assays for 5F...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC533989/ https://ncbi.nlm.nih.gov/pubmed/15572680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10766-10776.2004 |
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