5-Fluorouracil Enhances Exosome-Dependent Accumulation of Polyadenylated rRNAs

The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of solid tumors. Although 5FU slows DNA synthesis by inhibiting the ability of thymidylate synthetase to produce dTMP, the drug also has significant effects on RNA metabolism. Recent genome-wide assays for 5F...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fang, Feng, Hoskins, Jason, Butler, J. Scott
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC533989/
https://ncbi.nlm.nih.gov/pubmed/15572680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10766-10776.2004
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares