5-Fluorouracil Enhances Exosome-Dependent Accumulation of Polyadenylated rRNAs

The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of solid tumors. Although 5FU slows DNA synthesis by inhibiting the ability of thymidylate synthetase to produce dTMP, the drug also has significant effects on RNA metabolism. Recent genome-wide assays for 5F...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Fang, Feng, Hoskins, Jason, Butler, J. Scott
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2004
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC533989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15572680/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.24.10766-10776.2004
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