5-Fluorouracil Enhances Exosome-Dependent Accumulation of Polyadenylated rRNAs

The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of solid tumors. Although 5FU slows DNA synthesis by inhibiting the ability of thymidylate synthetase to produce dTMP, the drug also has significant effects on RNA metabolism. Recent genome-wide assays for 5F...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Fang, Feng, Hoskins, Jason, Butler, J. Scott
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2004
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC533989/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15572680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.24.10766-10776.2004
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