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A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish

T cells are an evolutionarily conserved feature of the adaptive immune systems of vertebrates. Comparative studies using evolutionarily distant species hold great promise for unraveling the genetic landscape underlying this process. To this end, we used ENU mutagenesis to generate mutant zebrafish w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lawir, Divine-Fondzenyuy, Iwanami, Norimasa, Schorpp, Michael, Boehm, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339814/
https://ncbi.nlm.nih.gov/pubmed/28266617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44145
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