RUNX1 cooperates with FLT3-ITD to induce leukemia

Acute myeloid leukemia (AML) is induced by the cooperative action of deregulated genes that perturb self-renewal, proliferation, and differentiation. Internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase are common mutations in AML, confer poor prognosis, and stimulate myeloprolif...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Behrens, Kira, Maul, Katrin, Tekin, Nilgün, Kriebitzsch, Neele, Indenbirken, Daniela, Prassolov, Vladimir, Müller, Ursula, Serve, Hubert, Cammenga, Jörg, Stocking, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339673/
https://ncbi.nlm.nih.gov/pubmed/28213513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160927
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