FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia

The inversion of chromosome 16 in the inv(16)(p13q22) is one of the most frequent cytogenetic abnormalities observed in acute myeloid leukemia (AML). The inv(16) fuses the core binding factor (CBF) beta subunit with the coiled-coil rod domain of smooth muscle myosin heavy chain (SMMHC). Expression o...

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Main Authors: Kim, Hyung-Gyoon, Kojima, Kyoko, Swindle, C. Scott, Cotta, Claudiu V., Huo, Yongliang, Reddy, Vishnu, Klug, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214774/
https://ncbi.nlm.nih.gov/pubmed/17967943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-030312
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