Fitness Costs Limit Viral Escape from Cytotoxic T Lymphocytes at a Structurally Constrained Epitope

The intense selection pressure exerted by virus-specific cytotoxic T lymphocytes (CTL) on replicating human immunodeficiency virus and simian immunodeficiency virus results in the accumulation of CTL epitope mutations. It has been assumed that fitness costs can limit the evolution of CTL epitope mut...

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Detalles Bibliográficos
Main Authors: Peyerl, Fred W., Bazick, Heidi S., Newberg, Michael H., Barouch, Dan H., Sodroski, Joseph, Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC533946/
https://ncbi.nlm.nih.gov/pubmed/15564498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13901-13910.2004
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