Compensatory Substitutions Restore Normal Core Assembly in Simian Immunodeficiency Virus Isolates with Gag Epitope Cytotoxic T-Lymphocyte Escape Mutations

The evolution of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) as they replicate in infected individuals reflects a balance between the pressure on the virus to mutate away from recognition by dominant epitope-specific cytotoxic T lymphocytes (CTL) and the struc...

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Bibliographic Details
Main Authors: Yeh, Wendy W., Cale, Evan M., Jaru-Ampornpan, Pimkwan, Lord, Carol I., Peyerl, Fred W., Letvin, Norman L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563819/
https://ncbi.nlm.nih.gov/pubmed/16873273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00068-06
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