Simian-Human Immunodeficiency Virus Escape from Cytotoxic T-Lymphocyte Recognition at a Structurally Constrained Epitope

Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequ...

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Bibliographic Details
Main Authors: Peyerl, Fred W., Barouch, Dan H., Yeh, Wendy W., Bazick, Heidi S., Kunstman, Jennifer, Kunstman, Kevin J., Wolinsky, Steven M., Letvin, Norman L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC262601/
https://ncbi.nlm.nih.gov/pubmed/14610180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.23.12572-12578.2003
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