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Use of Molecular Beacons for Rapid, Real-Time, Quantitative Monitoring of Cytotoxic T-Lymphocyte Epitope Mutations in Simian Immunodeficiency Virus

Immune pressure on lentiviruses exerted by cytotoxic T lymphocytes (CTL) selects for virus CTL epitope mutations. Currently employed methods for monitoring emerging CTL epitope mutations rely on the labor-intensive and time-consuming techniques of virus population or clonal sequencing. Here we descr...

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Autors principals: Peyerl, Fred W., Barouch, Dan H., Bazick, Heidi S., Manuel, Edwin, Letvin, Norman L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234110/
https://ncbi.nlm.nih.gov/pubmed/16145140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.43.9.4773-4779.2005
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