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UGT1A1 polymorphisms in cancer: impact on irinotecan treatment
Mutations in the UGT1A1 gene have been implicated in Gilbert syndrome, which shows mild hyperbilirubinemia, and a more aggressive childhood subtype, Crigler–Najjar syndrome. To date, more than 100 variants have been found in the UGT1A1 gene. Among them, UGT1A1*28 and UGT1A1*6 have been reported to b...
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| Veröffentlicht in: | Pharmgenomics Pers Med |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338934/ https://ncbi.nlm.nih.gov/pubmed/28280378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S108656 |
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